Job DescriptionThe Oh lab (www.ohlabs.org) at Massachusetts General Hospital and Harvard Medical School is seeking a post-doctoral fellow interested in biochemistry and/or cell biology.
Our lab studies how the ubiquitin-proteasome system (UPS) masterminds key decision-making events, including cell cycle progression, gene expression control, and tissue type specification. We also strive to understand how dysfunction of the UPS contributes to various malignancies. Our group recently identified how the E3 ubiquitin ligase APC/C (anaphase promoting complex) controls the pluripotent identity of human embryonic stem cells by enabling the activation of stem cells genes upon exit from mitosis (Nature, PMID: 32076268). We are currently working towards understanding the prevalence of APC/C-dependent regulation in other tissue types, including those of tumorigenic origin, and characterizing the molecular basis of this mechanism. Some of our other ongoing projects include (i) deciphering the chromatin-bound ubiquitin code, (ii) elucidating a systems-level framework for the UPS, and (iii) developing small molecule inhibitors that co-opt the ubiquitin machinery (PROTACs) to target tumor substrates. To tackle these broad areas, we employ a multidisciplinary approach, combining global and quantitative analyses with hypothesis-driven, mechanistic studies.
We are seeking a self-motivated investigator who has a solid background in biochemistry and/or cell biology. The ideal candidate is a strong bench scientist who can think creatively and has a proven track of success in a laboratory setting (i.e. a first author publication). A PhD and/or MD is required for this position and the degree must be conferred within the last three years. The candidate will be expected to carry out an independent research project under the guidance of Dr. Oh and will hold joint academic appointments at the Center for Cancer Research, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School. Additionally, our lab is part of an exceptionally collaborative department (https://bit.ly/30vsrLQ), and the candidate will have numerous opportunities to engage with both basic scientists and clinicians.
Interested candidates should submit a cover letter and a CV to Dr. Oh at firstname.lastname@example.org. Further information can be found at www.ohlabs.org.