Postdoctoral Research Fellow

Georgetown University, Medstar Georgetown Transplant Institute.

Washington DC, DC

Job posting number: #7078673

Posted: May 19, 2021

Application Deadline: Open Until Filled

Job Description

A full time Postdoctoral Research position is available in the laboratory of Dr Udeme Ekong at Georgetown University School of Medicine at Washington, DC. Investigations in the lab are focused on studies aimed at identifying pathways that facilitate functional defects in regulatory T cells in autoimmune liver diseases – specifically UPR-dependent and independent pathways. Our other focus is studying the immune response to SARS-CoV-2 infection in children with solid organ transplants.

1) Should have immunobiology experience and a strong interest in T cell immunology, its regulation, and signaling pathways.
2) PhD or equivalent with strong background in immunology.
3) Must be proficient in flow cytometry, molecular biology techniques such as (but not limited to) qRT-PCR, Western Blot, Co-Immunoprecipitation, Transfection and Transduction techniques.
4) Proficiency in working with human tissue and blood required.
5) Should be highly motivated and display initiative and independence.

Examples of publications from our lab include:
1) Arterbery A, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto S, Martinez M, Hafler D, Kleinewietfeld M, *Ekong UD. Production of pro-inflammatory cytokines by monocytes in liver transplanted recipients with de novo autoimmune hepatitis is enhanced and induces TH1-like regulatory T cells. J Immunol 2016 May 15; 196(10): 4040-51. doi;10.4049/jimmunol.1502276. Epub 2016 Apr 18. PubMed PMID: 27183637.

2) Arterbery AS, Yao J, Ling A, Avitzur Y, Martinez M, Lobritto S, Deng Y, Gan G, Mehta S, Wang G, Knight J, *Ekong UD. Inflammasome priming mediated via Toll-like receptors 2 and 4, induces TH1-like regulatory T cells in de novo autoimmune hepatitis. Front. Immunol 2018 Jul, 9:1612. doi;10.3389/fimmu.2018.01612. PMID: 30072988.

3) Jie Yao, Saikat Paul, Andrew Libby, Jordan Patterson, Adam S. Arterbery, James Knight, Sameet Mehta, Christopher Castaldi, Guilin Wang, Yaron Avitzur, Mercedes Martinez, Steve Lobritto, Yanhong Deng, Gan Geliang, Andrew Mason, Margarita Dominguez-Villar, Malaiyalam Mariappan, *Ekong UD. HERV1-env dependent UPR activation is an initiator of T cell autoreactivity in autoimmune liver disease. Accepted, IN PRESS J Immunol May 2021.

Examples of scientific meeting presentations from our lab:
1) S Paul, S Royal, A Rozeboom, N Yazigi, S Kaufman, K Khan, C Matsumoto, A Kroemer, T Fishbein, *UD Ekong. Immune profiling of COVID-19 infection in pediatric solid organ transplantation. (A) American Association of Immunologists, Virtual Immunology 2021.

2) S Paul, S Royal, J Chahine, A Rozeboom, N Yazigi, S Kaufman, K Khan, C Matsumoto, A Kroemer, T Fishbein, *UD Ekong. Should we worry about SARS-CoV-2 infection in pediatric solid organ transplantation? (A) American Transplant Congress, ATC Virtual, June 2021.

Georgetown University is an affirmative action/equal opportunity employer. Applications from women and minority candidates are especially encouraged.

If interested, please send CV and names/addresses of at least three referees to Dr. Udeme Ekong at Udeme.D.Ekong@gunet.georgetown.edu

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