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Two Postdoctoral Positions

Weill Institute for Cell & Molecular Biology

Ithaca, NY

Job posting number: #7079768

Posted: June 11, 2021

Application Deadline: Open Until Filled

Job Description

Two postdoctoral positions are available in Dr. Haiyuan Yu’s group at Cornell University. Dr. Yu’s group
performs research in the broad area of Network Systems Biology with both high-throughput experimental (see Vo et al., Cell 2016; Tippens et al., Nature Genetics, 2020) and integrative computational (see Wang et al., Nature Biotechnology 2012; Kumar et al., Nature Methods, 2020) methodologies, aiming to understand gene functions and their relationships within complex molecular networks (protein-protein interactome and gene regulatory networks in particular) and how perturbations to such systems may lead to various human diseases. Representative publications from the lab can be found below. Please visit the lab website (www.yulab.org) for more information and a full list of publications.

First, an experimental (“wet-lab”) position is available to develop proteomics technologies and carry out large-scale functional proteomics projects (we have a lab-owned state-of-art Thermo Fusion Lumos machine). The ideal candidate should have a strong track record and extensive lab experience in molecular biology, biochemistry, cell biology, and/or genetics. Experience with protein biochemistry (i.e., cloning, purification, co-immunoprecipitation, etc.) and mass spectrometry is strongly preferred. Experience in network biology or systems biology is not required.

Second, an experimental (“wet-lab”) postdoctoral position in gene regulation and functional genomics is available. Dr. Yu’s group works closely with Dr. John Lis’s group with weekly joint group meetings. Drs Yu and Lis jointly advise PhD students and postdocs, and are co-PIs for a newly-established functional characterization center within the ENCODE consortium. We are looking for motivated post-doctoral researchers to develop innovative functional genomic technologies to understand the fundamental architecture of transcriptional regulatory elements (enhancers and promoters), the impact of noncoding mutations on gene regulation, and how gene regulation changes genome wide under various disease conditions. Specifically, we will build upon the technologies that we have developed/implemented here across the two groups, such as Clone-seq, eSTARR-seq, and PRO-seq. The ideal candidate should have a strong track record and extensive lab experience in molecular biology, biochemistry, cell biology, and/or genetics. Experience with next-generation sequencing techniques is strongly preferred. Experience in network biology or systems biology is not required.

The starting date is flexible and can be as early as Fall 2021. Applications will be accepted until the position is filled. Competitive salary commensurate with experience and skills, as well as a generous benefits package will be offered. Interested applicants should send a PDF with CV, a brief description of future research interests (optional), and contact information for three references to Dr. Haiyuan Yu
(haiyuan.yu@cornell.edu). Please include “Yu Lab Postdoc 2021” in the subject line. Informal inquiries are welcome.

Selected Publications:
• Transcription imparts architecture, function, and logic to enhancer units, Nature Genetics, 2020
• An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders, Nature Genetics, 2018
• A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to
Human, Cell, 2016.
• A Massively Parallel Pipeline to Clone DNA Variants and Examine Molecular Phenotypes of Human
Disease Mutations, PLoS Genetics, 2014.
• Integrative annotation of variants from 1,092 humans: application to cancer genomics, Science, 2013.
• Three-dimensional reconstruction of protein networks provides insight into human genetic disease,
Nature Biotechnology, 2012.



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Job posting number:#7079768
Application Deadline:Open Until Filled
Employer Location:Cornell University
Ithaca,New York
United States
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