Job DescriptionA postdoc position is available immediately, in Dr. Dean Tang’s laboratory (https://www.roswellpark.org/dean-tang), to study a NIH grant-supported project that investigates the in-depth molecular and biochemical mechanisms of the tumor suppressor LRIG1 (Leucine-Rich Immunoglobulin-1). Studies from our lab have shown that LRIG1 behaves as a functional tumor suppressor ‘feedback’ induced by oncogenic signaling such as androgen receptor, MYC and ERBB (Li Q, et al., Nat. Commun. 10:5494, 2019; Ji Y. et al., Semin. Cancer Biol. 2021 Jan., Online ahead of print). We have recently observed that the LRIG1 gene further undergoes genomic amplifications in castration-resistant prostate cancer (CRPC) that has sustained AR and/or MYC amplifications. The main ongoing projects include: 1) investigating the tumor-suppressive functions of LRIG1 in novel genetic mouse models; 2) uncovering the novel LRIG1-interacting protein partners in both androgen-dependent and androgen-independent prostate cancers; and 3) developing novel LRIG1-based peptide therapeutics.
Potential candidates should have received solid Ph.D training in molecular biology and biochemistry as evidenced by quality peer-reviewed publications. Candidates with strong cancer biology knowledge, especially the working experience on prostate cancer or other hormone-regulated cancers, are strongly encouraged to apply. Suitable candidates should submit the NIH biosketch and/or full CV with the names of 3 referees to:
Dr. Dean Tang
Chair & Professor
c/o Susan Bechtel
Department of Pharmacology & Therapeutics
Roswell Park Comprehensive Cancer Center
Buffalo, NY 14263