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Postdoctoral Researcher in Targeted Nanoparticle Drug Delivery

Sandia National Laboratories

Livermore, CA

Job posting number: #7085395 (Ref:678364)

Posted: September 16, 2021

Job Description

This posting will be open for application submissions for a minimum of seven (7) calendar days, including the ‘posting date’. Sandia reserves the right to extend the posting date at any time. : Are you looking for an opportunity to do impactful and creative research? Sandia/California’s Biotechnology and Bioengineering Department is seeking a dedicated and hardworking Postdoc to join an interdisciplinary team developing targeted nanoparticles for drug delivery to tissues, particularly across the blood-brain-barrier. You will help the team develop nanoparticle formulations for drug delivery with an emphasis on targeting ligand conjugation and lipid nanoparticle library development for in vitro and in vivo screening. On any given day, you may be called on to: + Synthesize and characterize nanoparticle formulations for optimal performance as drug vehicles + Design and evaluate targeting moieties to enable tissue specific delivery + Help develop libraries of formulations for in vitro and in vivo screening + Analyze and interpret results as part of a cross-disciplinary team + Publish scientific papers in peer-reviewed journals and present findings at seminars and conferences

Required:
+ PhD in Material Science, Organic Chemistry, Bioengineering, or other relevant field + Ability to conduct and communicate creative, independent research demonstrated by a record of high technical accomplishment (e.g. publication in high-impact scientific journals, presentations at national/international conferences)

Desired:
Familiarity with one or more of the following: + Characterization methods (e.g. transmission electron microscopy (TEM), dynamic light scattering and zeta potential measurements) + Lipids, liposome synthesis and/or membrane science + Protein engineering, conjugation and modification + Immunochemistry and ligand binding + Surface science and functionalization + Prior experience in a BSL-2 laboratory

Department Description:

Biotechnology and Bioengineering Department, located in Livermore, and Emeryville, CA, performs both basic and applied biological and bioengineering research with broad applications in national security. We address problems such as biodefense and health security, developing advanced technology including micro- and nanofluidics and engineered automated systems, and new research approaches which include gene-editing and novel nanomaterials. We also address national energy security by developing the science and engineering required to be able to produce clean, efficient, and cost-effective biofuels, specialty chemicals and polymers on a commercial scale. This work is carried out in partnership with the Department of Energy's Joint BioEnergy Institute (JBEI) as well as other external academic and commercial partners. The department is highly multidisciplinary and is comprised of researchers with expertise in many fields of biology, chemistry and engineering.

About Sandia:

Sandia National Laboratories is the nation’s premier science and engineering lab for national security and technology innovation, with teams of specialists focused on cutting-edge work in a broad array of areas. Some of the main reasons we love our jobs:• Challenging work with amazing impact that contributes to security, peace, and freedom worldwide• Extraordinary co-workers• Some of the best tools, equipment, and research facilities in the world• Career advancement and enrichment opportunities• Flexible work arrangements for many positions include 9/80 (work 80 hours every two weeks, with every other Friday off) and 4/10 (work 4 ten-hour days each week) compressed workweeks, part-time work, and telecommuting (a mix of onsite work and working from home)• Generous vacations, strong medical and other benefits, competitive 401k, learning opportunities, relocation assistance and amenities aimed at creating a solid work/life balance* World-changing technologies. Life-changing careers. Learn more about Sandia at: http://www.sandia.gov*These benefits vary by job classification.

Security Clearance:

This position does not currently require a Department of Energy (DOE) security clearance. Sandia will conduct a pre-employment drug test and background review that includes checks of personal references, credit, law enforcement records, and employment/education verifications. Furthermore, employees in New Mexico need to pass a U.S. Air Force background screen for access to Kirtland Air Force Base. Substance abuse or illegal drug use, falsification of information, criminal activity, serious misconduct or other indicators of untrustworthiness can cause access to be denied or terminated, resulting in the inability to perform the duties assigned and subsequent termination of employment. If hired without a clearance and it subsequently becomes necessary to obtain and maintain one for the position, or you bid on positions that require a clearance, a pre-processing background review may be conducted prior to a required federal background investigation. Applicants for a DOE security clearance need to be U.S. citizens. If you hold more than one citizenship (i.e., of the U.S. and another country), your ability to obtain a security clearance may be impacted. Members of the workforce (MOWs) hired at Sandia who require uncleared access for greater than 179 days during their employment, are required to go through the Uncleared Personal Identity Verification (UPIV) process. Access includes physical and/or cyber (logical) access, as well as remote access to any NNSA information technology (IT) systems. UPIV requirements are not applicable to individuals who require a DOE personnel security clearance for the performance of their SNL employment or to foreign nationals. The UPIV process will include the completion of a USAccess Enrollment, SF-85 (Questionnaire for Non-Sensitive Positions) and OF-306 (Declaration of for Federal Employment). An unfavorable UPIV determination will result in immediate retrieval of the SNL issued badge, removal of cyber (logical) access and/or removal from SNL subcontract. All MOWs may appeal the unfavorable UPIV determination to DOE/NNSA immediately. If the appeal is unsuccessful, the MOW may try to go through the UPIV process one year after the decision date.

EEO Statement:

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, or veteran status and any other protected class under state or federal law. : Sandia demonstrates its commitment to public safety in the national interest by requiring that all new hires attest to their vaccination status before commencing employment. Currently, OPEIU-represented employees are excluded from the vaccination requirement. The requirement also applies to those who are telecommuting and working virtually. Any concerns about the ability to meet this requirement should be directed to HR Solutions at (505) 284-7400.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status.


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