Project Scientist – Novel cell death mechanisms, KS Chan Lab

Cedars-Sinai Medical Center

Los Angeles, CA

Job posting number: #7107613 (Ref: HRC0968809)

Posted: August 9, 2022

Application Deadline: Open Until Filled

Job Description

Are you ready to be a part of breakthrough research? Apply and join our team!

Dr. Keith Syson Chan’s laboratory is seeking a Project Scientist to investigate non-classical mechanisms of therapy resistance, including but not limited to cell death-induced cancer stem cell repopulation [Nature 517, 209–213(2015)], and immunosuppression [Nature Communications 11: 6299 (2020)]. This project will build on existing mass spectrometry proteomics data to dissect a novel molecular complex in regulating inflammatory cell death mechanisms, and their connections to downstream biologic processes, e.g., immune regulation.

Ideal candidate will be a self-motivated individual enthusiastic to interact with other lab members and the PI, he/she is most welcome to bring new ideas to drive project directions. Expertise in molecular biology of lytic cell death mechanisms, with extensive experience in molecular biology for analyzing protein-protein interaction, molecular complex formation, CRISPR-Cas9 technology for site specific mutations to disrupt protein domain interaction will be highly preferred. Experience in drug screening platforms will be desirable but not required.

KS Chan lab is comprised of an interdisciplinary team, focusing on cancer research that can translate into early-phase clinical trials or biomarkers to impact patients. We integrate cutting edge single-cell technologies and various study models (e.g., patient-derived xenografts, syngeneic murine models, GEMM) to address key research questions spanning: i) cell death-induced non-classical mechanisms of therapeutic resistance, ii) primary tumor and metastatic niche, and iii) emerging immunologic concepts that impact tumor progression and immune checkpoint response.

To learn more:

Primary Duties and Responsibilities:

  • The design of research directions and experiments in cooperation with the mentor. Will keep appropriate experimental records and analyze the results with the PI.
  • Explore literatures and state-of-the-art techniques relevant to the project.
  • Compiling figures and text for the submission of publications and presentations as primary author or co-author.
  • Highly encouraged to apply for fellowship or career transition grant application for career advancement.


Grow your career at Cedars-Sinai!

Cedars-Sinai is a nonprofit academic healthcare organization serving the diverse Los Angeles community and beyond. We are one of the leading institutes for competitive research funding from the National Institutes of Health. As an international leader in biomedical research, we translate discoveries into successful treatments with global impact. Cedars-Sinai is a hub for biomedical research with discoveries occurring in 26 departments and institutes that encompass the full spectrum of medicine.

Essential Job Responsibilities:

  • Participate and present at lab meetings, research-oriented interest groups, and attend departmental or cancer center seminar series

Required Experience:

  • PhD or Highest Degree in the field. Demonstrated significant, original, and creative contributions to a research or creative program or project
  • Completion of postdoctoral appointment in area of specialization, as applicable.


Working Title:Project Scientist – Novel cell death mechanisms, KS Chan Lab
Department:Home Dept - Hem - Onc
Business Entity:Academic / Research
Job Category:,Academic/Research,Academic/Research
Job Specialty:Academic/Research Services
Position Type:Full-time
Shift Length:8 hour shift
Shift Type:Day

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at [email protected] and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

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