Dana-Farber Cancer Institute is seeking an experienced PhD-level scientist to join the antibody discovery and antibody-based therapeutics development-focused LAUNCHPAD or the Lab for Antibody and Nanobody Phage Display and Discovery. A pre-clinical strategic center, LAUNCHPAD’s mission is to streamline “discovery to translation” of antibody-based immunotherapies for cancer. The LAUNCHPAD team works closely with academic partners to design experimental strategies to identify promising antibody ‘hits’ as well as engineering hits to generate potential therapeutic bispecific and CAR T-cell immunotherapies. The candidate should be an exceptionally motivated individual with a passion for working in multidisciplinary teams to design, screen and engineer immunotherapy candidates and advance next-generation therapies.

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The Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allied in the common mission of conquering cancer. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to all patients; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.Â

• PhD scientist with experience in antibody screening, engineering and/or CAR-T engineering. A candidate with a M.S. degree and substantial experience (>7 years) may also be considered for this role. Industry research experience is a plus.
• Strong track record, hands-on experience, and in-depth knowledge in at least two of the following domain areas:
• antibody discovery (phage and yeast display strategies, affinity maturation approaches, etc.);
• antibody expression and characterization technologies including but not limited to purity and mispairing (SEC), aggregation/stability (DLS) as well as affinity characterization (SPR);
• generative AI tools for protein or antibody design (exposure and familiarity to Alphafold3, RoseTTAFold, ProteinMPNN, MOE and/or other bioinformatic tools for protein modeling and de novo protein design)
• Previous hands-on experience engineering antibody and/or CAR-T candidates and executing key functional assays for candidate screening (assessments of cytotoxicity via plate-based or imaging-based assays, tonic signaling, developability, etc.).
• ExceptionallyÂself-motivated and capable of taking scientific initiatives
• Excellent communication (written and verbal) and troubleshooting skills as well as the ability to work with a wide variety of collaborators.Â
• Outstanding planning, organizational, and multi-tasking skills.
• Must consider attention to detail a strength.Â
• Ability to work within a fast-paced team environment.Â

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Only applicants that submit a cover letter and a detailed CV will be considered. Following a pre-screen interview, the candidate will be requested to provide the contact information for three references.

Pay Transparency Statement

The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.

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For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA)

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$80,000 - $83,000 - SCIENTIST I

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At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we.ÂIf working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.