Job Description
Join the transformative team at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. our dedicated and compassionate employees are driven by a common mission: To deliver the cures of tomorrow to the people who need them today.
City of Hope seeks a Flow Cytometry Core Director to lead a high-performance shared resource supporting basic, translational, and clinical cancer research. The Director manages daily operations, technology development, and scientific support for advanced multi-parameter and spectral cytometry and sterile cell sorting. This role reports to the Associate Director of Shared Resources and supports major programs in immunotherapy, hematologic malignancies, solid tumor immunology, stem cell transplantation, and diabetes.
As a successful candidate you will:
Strategic & Scientific Leadership
Set scientific direction and operational strategy for the Flow Cytometry Core, maintaining its exceptional rating.
Evaluate and implement new technologies, instrumentation, and workflows.
Provide expert consultation on experimental design, multicolor/spectral panel development (20–40+ colors), data interpretation, and troubleshooting.
Oversee operation, QC, and maintenance of flow analyzers, spectral cytometers (e.g., Cytek Aurora), and multi-laser sorters.
Align the core with institutional priorities and shared resource standards; prepare quarterly oversight reports.
Operational Oversight
- Manage daily operations, including sample processing, scheduling, maintenance, QC, and SOP adherence.
- Ensure compliance with biosafety, aerosol management, federal regulations, and NCI CCSG guidelines.
Instrument & Technology Management
- Direct acquisition, lifecycle planning, service contracts, calibration, and troubleshooting for all cytometry equipment.
User Support & Training
- Provide scientific consultation and hands-on guidance for investigators.
- Develop and deliver user training programs; maintain clear communication, policies, and guidelines.
Quality Assurance & Data Integrity
- Establish and monitor QA/QC systems for instruments, reagents, and assays.
- Ensure reproducible, high-quality data and proper data management practices.
Financial & Administrative Management
- Develop and manage budgets, recharge structures, service contracts, and cost-recovery models.
- Oversee procurement, billing, reporting, and CCSG-related documentation.
Staff Leadership
- Recruit, supervise, and mentor technical and scientific staff.
- Promote excellence, customer service, and continuous improvement; oversee training for self-service analyzers and handling of human samples.
Collaboration & Institutional Engagement
- Work closely with investigators, departments, and other cores to support collaborative research.
- Contribute to grant applications, letters of support, shared resource sections, and CCSG reporting.
- Represent the core at institutional meetings and inter-core committees.
Your qualifications should include:
- Ph.D. in Immunology, Cancer Biology, Cell Biology, or related field, or equivalent experience.
- 5+ years of hands-on flow cytometry experience, including sterile sorting of human samples.
- Demonstrated expertise in high-parameter (20–40+ color) flow or spectral panel design.
- Supervisory experience and strong communication skills in a service-oriented environment.
- Proven ability to design and troubleshoot complex cytometry workflows and support diverse research projects in cancer and diabetes.
Preferred qualifications
- Experience in an NCI-designated cancer center or shared resource facility.
- Familiarity with immunotherapy workflows, tumor microenvironment profiling, hematologic malignancy phenotyping, or CAR-T development.
- Experience with high-dimensional analysis tools (FlowJo plugins, OMIQ, Cytobank, R/Bioconductor).
Understanding of CCSG Shared Resource expectations and cross-core integration.
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer.
To learn more about our Comprehensive Benefits, pleaseCLICK HERE.
The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.
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